Continuous flow

D. Zhao, T. Su, C. Len, R. Luque, Z. Yang. Recent advances in the oxidative esterification of 5-hydroxymethylfurfural to furan-2,5-dimethylcarboxylate. Green Chem. 2022, 24, 6782-6789.
A. Richel, P. Maireles-Torres, C. Len. Recent advances in continuous reduction of furfural to added value chemicals. Curr. Opin. Green Sustain. Chem. 2022, 37, 100655.
R. Radjagobalou, V. Rouffeteau, A. Deleu, P. Nabokoff, J. Cossy, C. Len. Continuous flow Reductive Alkylation of Methanol by Aldehydes. Synthesis of O-Methyl Ethers and 1,1-Dimethoxyacetals. Mol. Catal. 2022, 524, 112321.
R. Nguyen, N. Galy, F.A. Alasmary, C. Len. Microwave-assisted continuous flow for the selective oligomerization of glycerol. Catalysts 2021, 11, 166.
M.R. Khodadadi, J. Thiel, R.S. Varma, C. Len. Innovative continuous synthesis of solketal. J. Flow Chem. 2021, https://doi.org/10.1007/s41981-021-00148-3
T. Su, D. Zhao, Y. Wang, H. Lu, R.S. Varma, C. Len. Innovative protocols in the catalytic oxidation of 5-hydroxymethylfurfural. ChemSusChem 2021, 14, 266-280.
Y. Wang, D. Zhao, R. Liang, K.S. Triantafyllidis, W. Yang, C. Len. Transfer hydrogenation of furfural to furfuryl alcohol over modified Zr-based catalysts using primary alcohols as H-donors. Mol. Catal. 2021, 111199.
M.R. Khodadadi, I. Malpartida, C.W. Tsang, C.S.K. Lin, C. Len. Recent advances on the catalytic conversion of waste cooking oil. Mol. Catal. 2020, 494, 111128.
D. Zhao, D. Rodriguez-Padron, K.S. Trianfyllidis, Y. Wang, R. Luque, C. Len. Microwave-assisted oxidation of hydroxymethyl furfural to added-value compounds over ruthenium based catalysts. ACS Sustainable Chem. Eng. 2020, 8, 3091-3102.
M. Audemar, Y. Wang, D. Zhao, S. Royer, F. Jerome, C. Len, K. De Oliveira Vigier. Synthesis of furfuryl alcohol from furfural: a comparison between batch and continuous flow reactors. Energies 2020, 13, 1002.
F. Delbecq, M.R. Khodadadi, D.R. Padron, R.S. Varma, C. Len. Isosorbide: recent advances in catalytic production. Mol. Catal. 2020, 482, 110648.
Y. Wang, D. Zhao, D.R. Padron, C. Len. Recent advances in catalytic hydrogenation of furfural. Catalysts 2019, 9, 796-828.
C. Len, R. Luisi. Catalytic methods in flow chemistry. Catalysts 2019, 9, 663-665.
D. Zhao, Y. Wang, F. Delbecq, C. Len. Continuous flow conversion of alkyl levulinates into γ-valerolactone in the presence of Ru/C as catalyst. Mol. Catal. 2019, 475, 110456.
L. Daviot, T. Len, C.S.K. Li, C. Len. Microwave-assisted homogeneous acid catalysis and chemoenzymatic synthesis of dialkyl succinate in a flow reactor. Catalysis 2019, 9, 272-281.
E. Doustkhah, J. Lin, S. Rostamnia, C. Len, R. Luque, X. Luo, Y. Bando, K.C.W. Wu, J. Kim, Y. Yamauchi, Y. Ide. Development of sulfonic-acid-functionalized mesoporous materials: synthetic and catalytic applications. Chem. Eur. J. 2019, 25, 1614-1635.
R. S. Varma, C. Len. Recent advances in glycerol valorization in continuous flow process. Curr. Opin. Green Sustain. Chem. 2019, 15, 83-90.
D. Zhao, P. Prinsen, Y. Wang, W. Ouyang, F. Delbecq, C. Len, R. Luque. Continuous flow alcoholysis of furfuryl alcohol to alkyl levulinates using zeolites. ACS Sustainable Chem. Eng. 2018, 6, 6901-6909.
W. Ouyang, D. Zhao, Y. Wang, A. Balu, C. Len, R. Luque. Continuous flow conversion of biomass-derived methyl levulinate into gamma valerolactone using functional metal organic framework. ACS Sustainable Chem. Eng. 2018, 6, 6746-6752.
Y. Wang, P. Prinsen, K.S. Triantafyllidis, S.A. Karakoulia, P.N. Trikalitis, A. Yepez, C. Len, R. Luque. Comparative study of supported monometallic catalysts in the liquid-phase hydrogenation of furfural : batch and continuous flow. ACS Sustainable Chem. Eng. 2018, 6, 9831-9844.
Y. Wang, P. Prinsen, K.S. Triantafyllidis, S.A. Karakoulia, A. Yepez, C. Len, R. Luque. Batch vs continuous flow performance of supported mono- and bimetallic nickel catalysts for catalytic transfer hydrogenation of furfural in isopropanol. ChemCatChem 2018, 10, 3459-3468.
S. Bruniaux, D. Luart, C. Len. Continuous flow reductive alkylation: synthesis of bio-based symmetrical and dissymmetrical ethers. Synthesis 2018, 50, 1849-1856.
C. Len, F. Delbecq, C.C. Corpas, E.R. Ramos. Continuous flow conversion of glycerol into chemicals : an overview. Synthesis 2018, 50, 723-740.
C. Len, S. Bruniaux, F. Delbecq, V.S. Parmar. Palladium-catalyzed Suzuki-Miyaura cross-coupling in continuous flow. In Suzuki-Miyaura cross-coupling reaction and potential applications, 2018, Eds. Ioannis D. Kostas, Catalysts MDPI, pp 1-23.
C. Len. Palladium-catalyzed cross-coupling in continuous flow at room and mild temperature. In Sustainable catalysis: energy-efficient reactions and applications, 2018, Eds. Rafael Luque - Frank Lam, Wiley, chp 7, pp 183-205.
F. Delbecq, R. Luque, C. Len. Microwaves in flow chemistry. In Microwave chemistry – Microwaves changes the way to work in chemical laboratories, 2017, Eds. Giancarlo Cravotto –Diego Carnaroglio, De Gruyter, chp 9, 149-166.
C. Len, S. Bruniaux, F. Delbecq, V.S. Parmar. Palladium-catalyzed Suzuki-Miyaura cross-coupling in continuous flow. Catalysts 2017, 7, 146-168.
N. Galy, R. Nguyen, P. Blach, S. Sambou, D. Luart, C. Len. Glycerol oligomerization in continuous flow reactor. J. Ind. Eng. Chem. 2017, 51, 312-318.
A. J. Garcia-Olmo, A. Yepez, A. M. Balu, P. Prinsen, A. Garcia, A. Mazière, C. Len, R. Luque. Activity of continuous flow synthesized Pd-based nanocatalysts in the flow hydroconversion of furfural. Tetrahedron 2017, 73, 5599-5604.
C. Cazorla, M. Billamboz, H. Bricout, E. Monflier, C. Len. Green and scalable palladium on carbon-catalyzed Tsuji-Trost coupling reaction using an efficient and continuous flow system. Eur. J. Org. Chem. 2017, 6, 1078-1085.
I. Polaert, L. Estel, D. Luart, C. Len, M. Delmotte. A new and original microwave continuous reactor under high pressure for future chemistry. AIChE Journal 2017, 63, 192-199.
N. Sotto, C. Cazorla, C. Villette, M. Billamboz, C. Len. Selective pinacol-coupling reaction using a continuous flow system. J. Org. Chem. 2016, 81, 11065-11071.
N. Sotto, C. Cazorla, C. Villette, M. Billamboz, C. Len. Toward the sustainable synthesis of biosourced divinylglycol from glycerol. ACS Sustainable Chem. Eng. 2016, 4, 6996-7003.
N. Galy, R. Nguyen, H. Yalgin, N. Thiebault, D. Luart, C. Len. Glycerol in sub- and supercritical solvents. J. Chem. Technol. Biotechnol. 2017, 92, 14-26.
E. Banaszak-Leonard, F. Mangin, C. Len. Barton decarboxylation under ultrasonic continuous flow. New J. Chem. 2016, 40, 7414-7420.
H. Yalgin, D. Luart, C. Len. First examples of Doebner-Miller reaction in flow: Efficient production of 2-methylquinoline derivatives in water. J. Flow Chem. 2016, 6, 80-85.
H. Saggadi, I. Polaert, D. Luart, C. Len, L. Estel. Microwaves under pressure for the continuous production of quinoline from glycerol. Catal. Today 2015, 255, 66-74.
C. Len, R. Luque. Continuous flow transformations of glycerol to valuable products: an overview. Sustainable Chem. Process. 2014, 2, 1-10.

Address

Chimie ParisTech

PSL University

CNRS

Institute of Chemistry for Life and Health Sciences

11, rue Pierre et Marie Curie

F-75005 Paris, France

Contact

Tel: +33 185 784 166

christophe.len@chimieparistech.psl.eu

Quick links

Chimie ParisTech

PSL University

CNRS

May 2020:

Yantao and Daily's paper titled "Insights into the selective oxidation of 5-hydroxymethylfurfural to 5-hydroxymethyl-2-furancarboxylic acid using silver oxide" is published in ACS Sustainable Chemistry and Engineering. Congratulations!

April 2020:

Our review titled "Lignocellulosic biomass for bioethanol: recent advances, technology trends and barriers to industrial development" is published in Current Opinion in Green and Sustainable Chemistry.

April 2020:

Professor Len's collaborative paper titled "Furfural Analogs as Sustainable Corrosion Inhibitors—Predictive Efficiency Using DFT and Monte Carlo Simulations on the Cu(111), Fe(110), Al(111) and Sn(111) Surfaces in Acid Media" is published in Sustainability.

March 2020:

Welcome: The Len group welcomes its new Master student Quoc-Thai Huynh.

February 2020:

Yantao and Daily's paper titled "Microwave-Assisted Oxidation of Hydroxymethyl Furfural to Added-Value Compounds over a Ruthenium-Based Catalyst" is published in ACS Sustainable Chemistry and Engineering. Congratulations!

February 2020:

Our collaborative paper titled "Synthesis of furfuryl alcohol from furfural: A comparison between batch and continuous flow reactors" is published in Energies. Congratulations!

January 2020:

Our collaborative paper titled "Characterization and Antioxidant Activity of Microwave-Extracted Phenolic Compounds from Biomass Residues" is published in ACS Sustainable Chemistry and Engineering. Congratulations!

January 2020:

Our paper titled "Catalysts for Suzuki–Miyaura Coupling Reaction" is published in Catalysts.

January 2020:

Welcome: The Len group welcomes its new visiting Lecturer Ting Su from the Yantai University (China).

December 2019:

Qi's paper titled "The prediction multi-phase, multi reactant equilibria by minimizing the Gibbs energy of the system: Review of available techniques and proposal of a new method based on a Monte Carlo technique" is published in Chemical Engineering Science. Congratulations!

November 2019:

Our collaborative paper titled "A review on high catalytic efficiency of solid acid catalysts for lignin valorization" is published in Bioresource Technology. Congratulations!

November 2019:

Frederic, Mohamad and Daily's paper titled "Isosorbide: Recent advances in catalytic production" is published in Molecular Catalysis. Congratulations!

October 2019:

Congratulation to Ms Anitha Muralidhara for her successful PhD defence.

October 2019:

Qi's paper titled "Theoritical analysis of the green synthesis of aniline by reduction of nitrobenzene" is published in Chemical Engineering Science. Congratulations!

October 2019:

Our collaborative paper titled "Synthetic, Structural, and Anticancer Activity Evaluation Studies on Novel Pyrazolylnucleosides" is published in Molecules. Congratulations!

September 2019:

Congratulation to Prof. Carol Sze Ki Lin from City University of Hong Kong for her seminar "Integrated bio refinery strategies for waste and biomass valorisation".

September 2019:

Professor Len's collaborative paper titled "Design and physicochemical properties of long and stiff fatty low molecular weight oleogelators" is published in Journal of Molecular Liquids.

September 2019:

Yantao's paper titled "Microwave-assisted catalytic upgrading of bio-based furfuryl alcohol to alkyl levulinate over commercial non-metal activated carbon" is published in Molecular Catalysis. Congratulations!

September 2019:

Yantao's paper titled "Recent advances in catalytic hydrogenation of furfural" is published in Catalysts. Congratulations!

August 2019:

Professor Len's collaborative paper titled "Catalytic methods in flow chemistry" is published in Catalysts.

July 2019:

Congratulation to Prof. Virinder S. Parmar from City University of New York for his seminar "Natural-products inspired discovery and development of novel anti-inflammatory, antihypertensive and antimicrobial compounds".

July 2019:

Professor Len's collaborative paper titled "Rh catalyzed hydroformylation of divinylglycol : an effective way to access 2,7-dioxadecalin-3,8-diol" is published in European Journal of Organic Chemistry.

June 2019:

Welcome: The Len group welcomes its new visiting PhD student Daily Rodriguez-Padron from the University of Cordoba (Spain).

June 2019:

Deyang's paper titled "Continuous flow conversion of alkyl levulinates into γ-valerolactone in the presence of Ru/C as catalyst" is published in Molecular Catalysis. Congratulations!

May 2019:

Yantao's paper titled "Mechanistic insights into the microwave-assisted cinnamyl alcohol oxidation using supported iron and palladium catalysts" is published in Molecular Catalysis. Congratulations!

May 2019:

Sophie's paper titled "A novel strategy for selective O-methylation of glycerol in subcritical methanol" is published in Frontiers in Chemistry. Congratulations!

April 2019:

Welcome: The Len group welcomes our new postdoctoral fellow Dr Mohamad Reza Khodadadi.

March 2019:

Laura's paper titled "Microwave-assisted homogeneous acid catalysis and chemoenzymatic synthesis of dialkyl succinate in a flow reactor" is published in Catalysis. Congratulations!

March 2019:

Congratulation to Mr Yantao Wang for his successful PhD defence.

March 2019:

Deyang's paper titled "One-pot FDCA diesters synthesis from mucic acid and thier solvent-free regioselective polytransesterification for production of glycerol-based furanic polyesters" is published in Molecules. Congratulations!

March 2019:

Professor Len's collaborative paper titled "Design of new antifungal dithiocarbamic esters having bio-based acrylate moiety" is published in ACS Omega.

March 2019:

Professor Len's collaborative paper titled "Efficient liquid-assisted grinding selective aqueous oxidation of sulfides using supported heteropolyacid catalysts" is published in ChemCatChem.

January 2019:

Qi's paper titled "Sensitivity of the predictability of chemical equilibrium software to choice of the products" is published in Industrial & Engineering Chemistry Research. Congratulations!

December 2018:

Anitha's paper titled "Humins in the environment. Early stage insights on ecotoxicological aspects" is published in BioFPR. Congratulations!

December 2018:

Qi's paper titled "Improving the predictability of chemical equilibrium software" is published in Industrial & Engineering Chemistry Research. Congratulations!

November 2018:

Professor Len's collaborative paper titled "Recent advances in glycerol valorization in continuous flow process" is published in Curr. Opin. Green Sustain. Chem.

November 2018:

Professor Len's collaborative paper titled "Development of sulfonic-acid-functionalized mesoporous materials: synthetic and catalytic applications" is published in Chem. Eur. J.

Disclaimer: This website is the sole responsibility of Prof. Christophe Len. Paris Sciences & Lettres and Chimie ParisTech are not responsible for its content. Reproduction in whole or in part of this website in any form or medium is prohibited without the express written permission of Prof. Christophe Len.